Studies on the microsomal metabolism and binding of polybrominated biphenyls (PBBs).
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منابع مشابه
Studies on the microsomal metabolism and binding of polybrominated biphenyls (PBBs).
The metabolism of polybrominated biphenyls (PBBs) was studied in vitro by using rat liver microsomes in the presence of NADPH and atmospheric O2. Quantitative recoveries of all PBBs were obtained after incubations with control or 3-methylcholanthrene (MC) induced microsomes. Of the twelve major components, losses of only peaks 1 (2,4,5,2',5'-pentabromobiphenyl) and 3 (a hexabromobiphenyl) were ...
متن کاملToxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.
The composition, environmental fate, and effects of the polybrominated biphenyls (Firemaster BP-6 or FF-1) involved in the accidental contamination of cattle feed in Michigan in 1973 are reviewed. Toxic effects referred to in this report are limited to those occurring in domestic and laboratory animals and include general toxicity, neurobehavioral toxicity, immunotoxicity, reproductive toxicity...
متن کاملAbsence of plant uptake and translocation of polybrominated biphenyls (PBBs).
Studies of polybrominated biphenyl (PBB) uptake by plants have been conducted in hydroponic solutions and in greenhouse experiments with soil. Autoradiograms of corn and soybean seedlings grown in hydroponic solutions showed no translocation of 14C-PBB from 14C-PBB-treated solutions to plant tops or within the leaf from 14C-PBB-treated spots on the upper leaf surface. A significant portion of t...
متن کاملCutaneous effects of exposure to polybrominated biphenyls (PBBs): the Michigan PBB incident.
In 1973 an environmental accident occurred in northern Michigan in which 1000-2000 pounds of the toxic fire retardant polybrominated biphenyl (PBB) was added to the livestock food supply of much of northern Michigan. PBB is highly lipophilic. poorly metabolized, and biocumulative. It subsequently entered the human food chain of the entire state of Michigan. Health effects were noted in contamin...
متن کاملInduction of drug-metabolizing enzymes by fractionated commercial polybrominated biphenyls (PBBs).
Induction of Drug-Metabolizing Enzymes by Fractionated Commercial Polybrominated Biphenyls (PBBs). ROBERTSON, L., PARKINSON, A., AND SAFE, S. (1981). Toxicol. Appl. Pharmacol. 57, 254-262. A commercial polybrominated biphenyl mixture was separated chromatographically into two fractions on neutral alumina (AA and A,) and into three fractions on Florisil (FA, Fa, and Fc) by sequential elution wit...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1978
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.782351